Ctgf lncrna

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August undefined, 2024

WebDec 30, 2024 · The relative expression levels of lncRNA PVT1, CTGF, E-cadherin and vimentin were analyzed using reverse transfection-quantitative polymerase chain … WebJun 21, 2024 · A lncRNA known as lncRNA megacluster ( lnc-MGC) was found to play a key role in the pathogenesis of early DN ( 72 ). Lnc-MGC is a host gene for miR-379 cluster, i. e., harbors miRNAs in its exonic and intronic sequences and these non-coding RNAs are present within one of the largest miRNA clusters in the genome.

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WebJun 8, 2024 · BackgroundChronic liver fibrosis is an inevitable stage for the development of patients with chronic hepatitis B (CHB). However, anti-fibrotic therapies have been … WebJan 6, 2024 · The Hippo signaling pathway regulates cell proliferation and apoptosis, maintains tissue and organ size, and homeostasis of the internal environment of organisms. Abnormal expression of Yes-associated protein (YAP), the Hippo signaling pathway key component, is widely observed in various malignancies. Further, TAM, lncRNA, and … eagle creek road leavenworth wa

Exosomes in liver fibrosis: The role of modulating hepatic stellate ...

WebOct 7, 2024 · In conclusion, our study indicated that lncRNA H19 acted as a ceRNA to bind to miR-19b via a “sponge” to regulate the effect of CTGF on KGN cells, which may play a … WebE. Expression analysis of LITATS1, PAI-1, CTGF, and SMAD7 in MCF10A-M2 cells upon CRISPRa-mediated LITATS1 overexpression. Representative results from a minimum of three independent experiments are shown. ... TGF-β signaling can induce the expression of multiple lncRNAs, e.g., lncRNA-ATB and lncRNA-HIT, which function as effectors of … WebApr 12, 2024 · Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With advances in RNA sequencing technology, the focus of recent research has transitioned from studies of specific candidates to whole transcriptome analyses. Thanks to these … cs ihu

Frontiers Crosstalk Among YAP, LncRNA, and Tumor-Associated ...

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell …

WebMay 13, 2024 · lncRNA MIAT increases cell viability, migration, EMT and ECM production in age‑related cataracts by regulating the miR‑181a/CTGF/ERK signaling pathway May 2024 Experimental and Therapeutic ... WebApr 23, 2024 · LncRNA PFAL was found to have profibrotic activity, which manifested itself upon the inhibition of miR-18a. ... (TGF-β1) and connective tissue growth factor (CTGF) … csi humboldt pound townWebDec 12, 2024 · During the proliferative phase of diabetic wound healing, lncRNA H19 recruits the transcription factor SRF to the CTGF promoter region, activating CTGF and its downstream MAPK signaling pathway to accelerate fibroblast proliferation and wound healing. These findings elaborate lncRNA H19 as a regulator in the regenerative phase … eagle creek restaurant indianapolis

"WebOct 7, 2024 · Finally, luciferase reporter assays showed that the 3'-end sequences of lncRNA H19 and CTGF contained the binding site of miR-19b. In conclusion, our study … " - Ctgf lncrna

Ctgf lncrna

Long noncoding RNAs in cancer metastasis Nature Reviews

WebMar 10, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes. CTGF regulates biological ... WebJul 18, 2024 · Gene expression data analysis identified several genes, including Il6, Tgfb2, Cxcl1, Mmp13, Ctgf, Sost and lncRNA MALAT1, differentially regulated in co-cultures compared to monocultures. We also identified Sost as a regulator of MALAT1 in PC3 cells.

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WebMay 13, 2024 · LncRNA myocardial infarction associated transcript (MIAT) aberrant expression has been identified in a number of diseases, ... Connective tissue growth factor (CTGF), a downstream effector of TGF-β2, has been reported to be associated with several cellular functions, ... WebSep 22, 2024 · Noncoding RNAs (ncRNAs), including microRNA (miRNA) and long noncoding RNA (lncRNA), have been reported... LncRNA TUG1 acts as a competing …

WebJan 25, 2024 · Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle. Transforming growth factor β (TGF-β) as a pivotal cytokine/growth factor stimulates fibroblasts and hastens ECM production in injured … WebApr 23, 2024 · lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a. ... In the present study, we identified that lncRNA NONMMUT021928, …

WebCTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN … WebApr 9, 2024 · This has been supported by expression of specific protein-coding genes that facilitate organ-specific metastatic tropism (such as connective tissue growth factor (CTGF) in bone metastases 106 ...

WebApr 23, 2024 · LncRNA PFAL was found to have profibrotic activity, which manifested itself upon the inhibition of miR-18a. ... (TGF-β1) and connective tissue growth factor (CTGF) in acute respiratory distress ...

WebNov 7, 2024 · Connective-tissue growth factor (Ctgf), also known as cellular communication network 2 (Ccn2), is a candidate extracellular matrix (ECM) ... as Ctgf is … csi humboldt trainwreckWebCCN (for CYR61/ CTGF /NOV) proteins were identified originally from diverse cellular contexts and studied for their growth-promoting activities. It is now known that there are six CCN proteins in mammals. All are short (281–380aa) polypeptides that include four major domains, except for CCN5 that lacks a cysteine knot domain (Fig. 1).CCNs have several … csi humboldt reviewsWebSep 3, 2024 · Connective tissue growth factor (CTGF), also referred to as CCN2, belongs to the CCN (acronym for Cyr61, CTGF, ... The lncRNA AK139128 may be involved in this communication during IR, potentially as a regulator of cardiac remodeling. Other lncRNA have also been reported to participate in cardiac IR. eagle creek roaming backpack rfidWebLncRNA MSTRG.15746 and Il6 as well as lncRNA MSTRG.74451 and Il1f9 may have trans-regulatory relationships . These results suggested that lncRNAs and their targeted genes might be associated with the protective effect of itaconate, indicating that the regulatory role of lncRNAs is an ideal entry point to study the mechanism by which … csi how did warrick dieWebDec 14, 2024 · This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth … eagle creek rock quarry hartford ksWebJul 28, 2024 · PDF Cardiac fibrosis is closely related to multiple cardiovascular system diseases, and noncoding RNAs (ncRNAs), including long noncoding RNA (lncRNA)... Find, read and cite all the research ... csi hydraulic fittingsWebNov 1, 2024 · In summary, this experiment confirmed the role of lncRNA H19 as a ceRNA in KGN cells, which regulated the expression of CTGF through the lncRNA H19/miR-19b/CTGF regulatory axis, and Anally played an important role in the pathogenesis of PCOS. However, it should be noted that the ceRNA regulatory network is complex (21,22). csii australia holding pty ltd