Cyclothialidine
WebJan 1, 1993 · CYCLOTHIALIDINE, A NOVEL DNA GYRASE INHIBITOR 3.1. DISCOVERY, ISOLATION AND STRUCTURE ELUCIDATION The therapeutic progress achieved with …
Cyclothialidine
Did you know?
WebAbstract. The DNA gyrase inhibitor cyclothialidine was shown to be an interesting lead structure for the search of new antibacterials. During extensive work elucidating the structure-activity relations, it was demonstrated that variation of the lactone ring size of its bicyclic core was tolerated. Indeed, even ‘ seco ’ analogues exhibited ... WebMar 11, 2004 · Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of …
WebOct 1, 1994 · We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to... WebDec 11, 1996 · A total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was …
WebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products. WebCyclothialidine is an inhibitor of DNA gyrase. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. Cyclothialidine, CAS 147214-63-9 Please contact us for prices and availability for the specification of product you are interested at. Product consultation Purity : 98%
WebAntioxidative Antiviral Bioactive by-products Cyclosporin Analogue Set Enzyme inhibitors Mycotoxins Raw Materials of Healthcare Products Tacrolimus Analogue Set Others International : 1-631-504-6093 US & Canada (Toll free): 1-844-BOC (262)-0123 Fax: 1-631-614-7828 Email: [email protected] 45-16 Ramsey Road, Shirley, NY 11967, USA
WebAug 15, 2007 · From the SAR around cyclothialidine 2 we know that the introduction of a methoxy and a carboxylic ester group in the meta positions and a lipophilic group (like methyl) in para position to the phenol improves activity. Therefore we coupled the salicylic aldehyde 4a with various anilines to yield the acyclic benzylic amines 5 and the 2,3 … churchtown southport pubsWebApr 1, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the... churchtown st cuthbertsWebThecyclo- thialidinesarenaturallyoccurringcyclicpeptideinhibitors (Goetschietal., 1993), ofwhichGR122222Xisamember (Figure 1), andarealso inhibitors ofthe ATPase activity of the B subunit of DNAgyrase(Nakadaetal., 1994). dexter\u0027s world fishWebAug 26, 2024 · Cyclothialidine inhibits the ATPase activity of gyrase by competing for the ATP binding site . The precise mode of action of these agents with gyrase is incompletely understood, although ... churchtown southport restaurantsWebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products. churchtown st agnesWebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest … dexter\u0027s world bettasWebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... dexter\\u0027s world net worth