WebFeb 1, 2024 · 10.1152/ajpheart.00486.2024 Abstract Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 mice. WebAn electrocardiogram is a non-invasive procedure for recording electrical changes in the …
2281 - Gene ResultFKBP1B FKBP prolyl isomerase 1B [ (human)]
WebThe cardiac ryanodine receptor (RyR2) located on the sarcoplasmic reticulum (SR) controls intracellular Ca (2+) release and muscle contraction in the heart. Ca (2+) release via RyR2 is regulated by several physiological mediators. Protein kinase (PKA) phosphorylation dissociates the stabilizing FKBP12.6 subunit (calstabin2) from the RyR2 ... WebJul 18, 2024 · FKBP12 is a cytoplasmic peptidyl-prolylcis-transisomerase and is highly expressed in cardiomyocytes. Previously, it has been shown that FKBP12 regulates the skeletal muscle Ca2-release chan- nel ryanodine receptor (RyR)1 and excitation-contraction cou- pling in skeletal muscle (18). slow left join
Calcium Signaling: Calmodulin-Dependent Phosphatase - 百度学术
Webresults suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR. How phosphorylation of RyR affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6) are involved in heart failure WebFeb 15, 2006 · Heart failure is a leading cause of morbidity and mortality in the United … WebJul 19, 2024 · Here, we report the identification of DL001, a FKBP12-dependent rapamycin analog 40x more selective for mTORC1 than rapamycin. DL001 inhibits mTORC1 in cell culture lines and in vivo in C57BL/6J ... software pbs