Fkbp12-rapamycin binding
WebJun 30, 2015 · mTOR - Mammalian Target of Rapamycin, FRB domain - FKBP12-rapamycin associated protein, FKBP12 - FK506-binding protein 12, OPLS - Optimized Potentials for Liquid Simulations, Akt - RAC-alpha serine/threonine-protein kinase, PI3K - phosphatidylinositide 3-kinases. Molecular Docking studies of FKBP12-mTOR … WebThe fusion protein FAK-iFKBP did only show kinase activity by binding of Rapamycin together with the FRB protein. FAK is the focal adhesion kinase, whereas iFKBP is a …
Fkbp12-rapamycin binding
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WebApr 15, 2015 · Much of what is known about mTORC1 arose from studies using rapamycin, which binds to the FRB domain of mTOR along with FKBP12 (FK506-binding protein of 12 kDa) and inhibits its function[15]. mTORC1 is thus known as the rapamycin-sensitive complex. Compared to mTORC1, relatively little is known about the regulation of mTORC2. WebMay 23, 1995 · The full-length FRAP is a 289-kDa protein containing a putative phosphatidylinositol kinase domain. Using an in vitro transcription/translation assay method coupled with proteolysis studies, we have identified an 11-kDa FKBP12-rapamycin-binding domain within FRAP.
WebFKBP1A. Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene. [5] It is also commonly referred to as FKBP-12 or … WebSep 27, 2024 · The mammalian target of rapamycin (mTOR) is a serine-threonine kinase involved in cellular innate immunity, metabolism, and senescence. FK506-binding protein 12 (FKBP12) inhibits mTOR kinase activity via direct association. The FKBP12-mTOR association can be strengthened by the immunosuppressant rap …
WebFeb 12, 1999 · The FKBP12-rapamycin binding (FRB) domain in FRAP is also speculated to play an important role in FRAP function and signaling. However, the biochemical and … WebJun 30, 1994 · FKBP12-rapamycin inhibits progression through the G1 phase of the cell cycle in osteosarcoma, liver and T cells as well as in yeast, and interferes with mitogenic signalling pathways that are involved in G1 progression, namely with activation of the protein p70S6k (refs 5, 11-13) and cyclin-dependent kinases.
WebSep 14, 2024 · To stably inhibit TORC1, rapamycin must form a complex with a cellular protein called FKBP12 and the rapamycin-binding domain (the FRB domain) of a protein called mechanistic target of...
WebNov 9, 2007 · Rapamycin, in complex with FKBP12 (an FK506-binding protein), specifically interferes with mTORC1 function, and consequently, inhibits cell growth ( 4, 5 ). The major upstream regulators of mTORC1 are the TSC1 and TSC2 tumor suppressors. portland or airport hotels park and flyWebMar 6, 2016 · Instead, rapamycin binds to its intracellular receptor, FK506-binding protein 12 (FKBP12; ref. 21 ). The FKBP12–rapamycin complex binds to the FKBP12–rapamycin binding (FRB) domain of mTOR (amino acid residues 2025–2114), located immediately N-terminal to the kinase domain ( 22 ). portland or airport to newport orWebJul 12, 1996 · A crystal structure of the ternary complex of human FKBP12, rapamycin, and the FKBP12-rapamycin-binding (FRB) domain of human FRAP at a resolution of 2.7 … optima worldwide groupWebMay 23, 1995 · Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine … optima worldwide gas station incWebFK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/transpeptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/transconformations. optima workers compensationWeb上海康朗生物科技有限公司主要致力于“Anti-Phospho-mTOR (Ser2448)抗体”的生产销售。多年的“Anti-Phospho-mTOR (Ser2448)抗体”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前来选购。 联系电话:021-61998208。 optima worldwideWebFeb 19, 2024 · The binding mode of the 13 hits selected through the virtual screening procedure was analyzed by molecular docking by means of Glide software [27,28,29]. Initially, the rapamycin was docked in the same binding site to validate our protocol ; the obtained rapamycin poses were rescored by MM/GBSA method and the orientation … portland or all time high temperature