WitrynaThe human ERG (hERG) K+ channel has a crucial function in cardiac repolarization, and mutations or channel block can give rise to long … Witrynaassays using hERG cells. Figure 2. (A) 10 μg/well hERG membranes were incubated with 3.0 nM [3H]-Astemizole and increasing concentrations of unlabeled compounds in a 96-well plate. (B) 20 μg/well hERG membranes were incubated with 2 nM [3H]-Dofetilide and increasing concentrations of unlabeled compounds in a 96-well plate. -10 -9 -8 -7 …
Frontiers NBD-Based Environment-Sensitive Fluorescent Probes …
Witryna1 cze 2024 · Indeed, this 2,4-diaryl-2,5-dihydropyrrole compounds family has an antimitotic effect in transformed cells but also against hERG channel (IC 50 = 3.5 … Witryna14 maj 2024 · Three environment-sensitive probes were developed for the hERG channel based on the nitrobenzoxadiazole fluorophore herein. After careful … bosch 5 core bit
hERG-deficient human embryonic stem cell-derived …
http://www.aurorabiomed.com/wp-content/uploads/2014/03/HEK-hERG-Cell-Line.pdf Witryna20 gru 2007 · Background HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Zobacz więcej hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Zobacz więcej A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by … Zobacz więcej This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased … Zobacz więcej The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human … Zobacz więcej Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to Zobacz więcej Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment … Zobacz więcej HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Zobacz więcej bosch 5 inch diamond grinder