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WebFor the remaining 5%, the substance with the defined knowledge of chemical structure (i.e., High Potency Category (HPC) rules) needs to be excluded from the application. However, the DST value for HPC chemicals has not yet been proposed. WebAug 1, 2015 · Abbreviation: HPC, High Potency Category Chemicals. Of the 266 chemicals in the DST database falling into the reactive domain, 56 were classified as HPC and 209 as non-HPC. One chemical, potassium dichromate, is inorganic, and falls outside of the applicability domain of the approach. flr48t6ww
Application of the dermal sensitization threshold concept to …
WebNov 30, 2024 · Bioassays that are mainly triggered by highly specific chemicals have been classified as category 1 bioassays in a previous study that proposed EBTs (Escher et al. 2024b ). These category 1 bioassays target highly specific, mainly receptor-mediated effects such as binding to hormone receptors. WebCyclic Acetates Cyclic and Non-Cyclic Terpene Alcohols Cyclopentanones and Cyclopentenones Ionones → Erratum Linalool and Related Esters Macrocyclic Ketones Macrocyclic Lactone and Lactide Derivatives Non-Cyclic Alcohols with Unsaturated Branched Chain Salicylates → Erratum Web29 rows · Aug 1, 2015 · Abbreviations: HPC, High Potency Category Chemicals. This approach for identifying HPC chemicals ... Based on the 18 chemicals for which NOELs in the HRIPT were determined, the … These guidelines have been developed specifically for fragrance ingredients and … It can be seen that the agreement is close, and in all cases the potency category … To evaluate the reliability of the murine local lymph node assay (LLNA), a test for … Quantitative relationships are derived, for skin sensitisation by alkylating agents, … The dataset of 363 chemicals (271 sensitisers and 92 non-sensitisers) were … Principles for predicting HPC chemicals. Since sensitisation potency is dependent … greendale trick or treat